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Adrenal Dysfunction / Thyroid Imbalance

Armour Thyroid® Shortage is Affecting your Patients

All too often we see Armour Thyroid® on back orders, or a sudden shortage for no reason. Because of this, many patients have had to try synthetic thyroid hormones as replacements.  Levothyroxine and liothyronine are a few of those replacements. Unfortunately people are finding that Natural Thyroid is the only form that correctly works for them, stating that when they take the replacements they do not feel as good as they once did.

The great news is that different strengths and various forms of Natural Thyroid can actually be compounded. We can even blend T4 and T3 pure powders in a very specific ration by prescription. Contact us for more information.

Many times, patients find that they cannot tolerate the fillers and excipients that are so commonly found in commercial tablets. One of the best things about compounding your medication we have the ability to customize dosage to make sure all inactive ingredients that are causing problems to be omitted. We can replace and substitute non-reactive fillers as well. Any questions you have, please feel free to contact us.

Adrenal Fatigue

The adrenal glands secrete cortisone, estrogen, and testosterone which are known as hormones. These hormones are extremely important  for both vitality and health. They also affect total body function. After your mid-life, the adrenal glands slowly become the major endogenous source of sex hormones in men and women. Both intense and prolonged emotion and/or physical stress that are associated with modern lifestyles or even chronic illness can lead to Adrenal Fatigue. This is an important factor that contributes to health conditions such as obesity to allergies.

Anti-oxidant and anti-inflammatory adrenal hormones such as cortisol help minimize negative and allergic reactions, such as autoimmune disorders and even cancer. These hormones closely affect the usage of carbs and fats, the conversion of fats and proteins into energy, and gastrointestinal and cardiovascular functions. Correct adrenal support is so important to complete the hormonal road to optimal health. This includes proper nutrition, getting the proper amount of sleep you need, making sure you exercise properly, have great stress management, and slowing down to make sure to regain the correct perspective on life, and replacing the deficient hormones.

Thyroid Hormone Therapy

Hyperthyroidism’s (low levels of thyroid hormone) symptoms include the following: heat and cold intolerance, hypotension, fatigue, fluid retention, headaches, low sexual desire, anxiety, depression, constipation, aching joints and muscles, memory impairment, deep voice, swollen neck, enlarged tongue, irregular menstrual periods, PMS, hypoglycemia, high cholesterol, weight gain, and more. So many, half in fact, of the people suffering from thyroid disease are completely unaware that they have this condition.

Although T3 (the active form triiodothyronine) and T4 (an inactive form of thyroxine that’s converted to T3 in the other areas of the body) are both secreted by the normal thyroid gland, many hypothyroid patients are only treated with levothyroxine which is a synthetic T4. Many of these patient’s symptoms remain and T3 may be needed for the best and most optimal thyroid replacement therapy. The only commercially available form of this T3 is an immediate release formulation of  synthetic liothyronine. This is quickly absorbed into the body and can cause serious side effects by resulting a higher then normal T3 concentrations throughout the entire body. These side effects can include heart palpitations. According to research, there is a need for T3 sustained-release preparations to avoid these serious effects.

A double blind, crossover, completely random study actually found that inclusion of T3 in the replacement thyroid hormone actuallt improved cognitive performance, physical status, mood, and neuropsychological function in patients with hypothyroid. Many of the patients (two-thirds to be precise) expressed that they preferred T4 plus T3, and tended to have a decrease in depression after T4 treatment alone. Talk to your doctor to consider the benefits in using sustained-released T3 in treating hypothyroidism, specifically when the levothyroxine (T4) response is incomplete.

J Endocrinol Invest 2002 Feb;25(2):106-9

Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations.
Click here to access the PubMed abstract of this article.

N Engl J Med 1999 Feb 11;340(6):424-9
Effects of thyroxine as compared with thyroxine plus triiodothyronine in patients with hypothyroidism.
Click here to access the PubMed abstract of this article.
Also, the FREE full text of this article is available online.

 

Endocr Pract. 2006 Jan-Feb;12(1):43-7.

Rectal administration of propylthiouracil in suppository form in patients with thyrotoxicosis and critical illness: case report and review of literature.
Click here to access the PubMed abstract of this article.


Chronic Fatigue Syndrome (CFS, Chronic Fatigue and Immuno-Deficiency Syndrome, CFIDS) and Fibromyalgia(FM, formerly called fibrositis) may manifest as hypothalamic, pituitary, and immune dysfunction.

Ann Allergy Asthma Immunol. 1999 Feb;82(2):185-91

Therapeutic effects of oral NADH on the symptoms of patients with chronic fatigue syndrome.
Click here to access the PubMed abstract of this article.


The combination of thyroid resistance, high reverse T3, and pituitary dysfunction, leads to inadequate effect in the thyroid in many, if not all, CFIDS/FM patients. Levothyroxine (T4) preparations are often ineffective for CFIDS/FM patients. A combination T3/T4 combination preparation or straight T3 (triiodothyronine) may be preferred. The best for many of the patients is T3, but a very short acting T3 Cytomel may be available at your neighborhood pharmacy which is a poor choice. It is a poor choice because the varying levels of blood cause problems like heart palpitations. Sustained-release compounded T3 might be the best treatment. Standard blood test, may lead to a incorrect dose, and not not achieve great results or benefits. The success of the treatment is really up to the expertise and dosing of the T3 or T4/T3 combinations and what the medicines makeup is.

Natural Therapies for CFIDS/FM: Proper nutritional supplements, proteins, and hormones can protect and enhance the immune system. Antioxidants may also be beneficial because free radicals play a role in causing damage to the immune system.

Vitamin B-12 levels are very often low in  CFIDS/FM patients. A adrenal gland or malfunctioning thyroid can actually decrease the bodies ability to absorb and use vitamin B-12. For a healthy nervous system , vitamin B-12 is essential. For many years it has been known that fatigue and depression can be caused by having low B-12 levels.

D-ribose greatly reduced patients clinical symptoms, that are suffering from chronic fatigue and fibromyalgia. This average energy increase on the VAS of 45% and even a improvement in well-being of 30%.

J Altern Complement Med. 2006 Nov;12(9):857-62
The use of D-ribose in chronic fatigue syndrome and fibromyalgia: a pilot study.
Click here to access the PubMed abstract of this article.

For more information about patient-specific Hormone Replacement Therapy, please contact our compounding pharmacist.